Abstract & Bio
 Title: “Forward and reverse genetics for functional genomics and breeding ”

 


Dr. Bradley Till received a PhD from the University of Oregon for his work on maize chloroplast biogenesis. From 2000-2002 he was a postdoctoral researcher in the lab of Dr. Steven Henikoff at the Fred Hutchinson Cancer Research Center, where he co-developed the strategy known as TILLING (Targeting Induced Local Lesions IN Genomes). This is a ‘reverse genetics’ approach that searches germplasm for mutations in any gene of interest to researchers. Once a seed carrying a mutant allele is identified, it can be grown, multiplied and it’s phenotype/performance can be studied. From 2002-2007 Dr. Till led the Seattle TILLING Project, which helped establish TILLING in a range of species including maize, rice, soybean, chickpea and Drosophila. He also developed the EcoTILLING method for discovery and characterization of natural nucleotide polymorphisms. Dr Till will explain the concepts of forward and reverse genetics, give an update on the latest methodological developments and share lessons learned and examples from TiLLING in a broad range of crops important for food security.